CopiOs Sponge Bone Void Filler: Engineering a Microenvironment Conducive for Bone Growth
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چکیده
INTRODUCTION: Composites of purified collagen and calcium phosphate salts have been widely used to produce osteoconductive scaffolds for fracture healing and spinal fusion. The effects of different calcium phosphate additives in a collagen scaffold was previously investigated in a rat model of ectopic bone formation induced by a mixture of bovine bone derived growth factors. It was found that osteoinductivity was significantly enhanced by moderately acidic dibasic calcium phosphate salts but inhibited by hydroxyapatite and -tricalcium phosphate [1]. In this study, the efficacy of a novel bone graft substitute CopiOs Sponge Bone Void Filler (composite of collagen and dibasic calcium phosphate) was studied in a rabbit radial critical size segmental defect model to compare with autograft and the predicate device Healos II Bone Graft Substitute (BGS).
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